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Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

Sunday, June 28, 2020 3:00 AM

Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

 

 

Authors: Ayal B. Gussow, Noam Auslander, Guilhem Faure, Yuri I. Wolf, Feng Zhang, Eugene V. Koonin.

published: June 10, 2020

 

 

Significance

The ongoing COVID-19 pandemic is an urgent, global threat. Here we analyze the genome of the virus that causes COVID-19, SARS-CoV-2, along with other members of the coronavirus family. Our analysis identifies crucial genomic features that are unique to SARS-CoV-2 and two other deadly coronaviruses, SARS-CoV and MERS-CoV. These features correlate with the high fatality rate of these coronaviruses as well as their ability to switch hosts from animals to humans. The identified features could represent crucial elements of coronavirus virulence, and allow for detecting animal coronaviruses that have the potential to make the jump to humans in the future.

 

To continue reading the full article please follow the linkhttps://www.pnas.org/content/early/2020/06/09/2008176117

PDF version: https://www.pnas.org/content/pnas/early/2020/06/09/2008176117.full.pdf