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TWiST Strengthens PARP Inhibitor Role in Ovarian Cancer

Monday, March 18, 2019

New analysis of the NOVA trial confirms clinical benefit from niraparib for patients with recurrent ovarian cancer. The benefit occurred both in patients with and in those without BRCA mutations. Medscape Medical News

Ripple Effect: Repackaged Losartan Recalled Due to Impurity

Monday, March 18, 2019

Legacy Pharmaceutical recalls 43 repackaged lots of losartan because of the presence of the probable carcinogen N-nitroso-N-methyl-4-aminobutyric acid (NMBA) in the active pharmaceutical ingredient. News Alerts

Immunotherapy Should Be First Line in Merkel Cell Carcinoma

Monday, March 18, 2019

Pembrolizumab demonstrated durable tumor control, a generally manageable safety profile, and favorable survival outcomes compared with historical data in advanced MCC. Medscape Medical News

From Bench to Bedside: ENDO 2019 Ties Science to Clinical Care

Monday, March 18, 2019

'What distinguishes ENDO from other meetings is that you get a curated view of what is the newest, hottest, and best in science, which you know...is going to be impacting care.' Medscape Medical News

Chemo for Early-Stage Prostate Cancer? RTOG 0521 Says Maybe

Monday, March 18, 2019

In major clinical trial, docetaxel, which is typically used in metastatic disease, improved outcomes in high-risk, early-stage disease. However, the survival results fell short of the trial target. Medscape Medical News

Phone Intervention for Patients Most At Risk Improves HbA1c

Monday, March 18, 2019

Pharmacist-led phone interventions to improve insulin adherence in patients with diabetes worked best when those at highest risk of noncompliance were targeted. Medscape Medical News

Stroke Mortality Down, but Global Burden Remains High

Monday, March 18, 2019

Although the global stroke mortality rate dropped substantially from 1990 to 2016, the global burden of stroke is still high, with more than 80 million stroke survivors, new data show. Medscape Medical News

WRAP-IT: Antibacterial Pouch Cuts Device Infections

Monday, March 18, 2019

The trial provides the first randomized data supporting prophylaxis with the long-available TYRX envelope, but cost continues to be a consideration. Medscape Medical News

Lifestyle Changes Do a Number on PSA Values

Monday, March 18, 2019

Two month's abstinence from a few of life's pleasures obviated the need for prostate biopsy in nearly half of men who adopted the lifestyle changes. Medscape Medical News

Novel Program Trains Nurse Practitioners to Manage Pain Patients

Monday, March 18, 2019

In a unique educational program, nurse practitioners learned how to examine patients with shoulder and knee pain and how to determine which patients require specialist referral. Medscape Medical News

Hopeful Heart: Team Care for Mood Plus HF Improves Wellbeing

Monday, March 18, 2019

There is hope for improving mood and quality of life for heart failure patients with depression, a new trial suggests. Two-pronged care by a nurse care manager plus a diverse team topped usual care. Medscape Medical News

Could Ultrasound Serve as an Early Bone Density Screening Tool?

Monday, March 18, 2019

A small study suggests ultrasound of the heel bone could be a preliminary way of assessing bone density. The idea has been around for more than 30 years but has never taken off, says an expert. Medscape Medical News

Autism, Depression Tied to Prenatal Maternal Infection

Monday, March 18, 2019

A study of more than 1.5 million children suggests those who had been exposed to maternal infection in utero are at significantly greater risk of developing autism or depression during their lifetime. Medscape Medical News

TAVR Low-Risk Studies Get Standing Ovation at ACC

Monday, March 18, 2019

The success of the two trials of transcatheter aortic valve replacement in low-surgical-risk patients stole the show at the ACC today. Medscape Medical News

New AHA/ACC CVD Primary Prevention Guideline

Sunday, March 17, 2019

As expected, the new document recommends generally against aspirin in primary prevention, and aims to make a 'one-stop shop' for clinicians. Medscape Medical News

AUGUSTUS Backs Apixaban 'Double Therapy' in Most AF Post-ACS, PCI

Sunday, March 17, 2019

The most safe and effective antithrombotic regimen may involve neither warfarin nor aspirin, suggested a trial that might allay bleeding-risk concerns in a tough-to-treat atrial fibrillation population. Medscape Medical News

Apple Watch Helps Detect AF: Is This the Future?

Saturday, March 16, 2019

The first study of its kind involving more than 400,000 members of the general population used an Apple Watch to identify irregular pulse and received a mixed response from ACC delegates. Medscape Medical News

HoT-PE Puts Early Discharge for Low-Risk PE on Front Burner

Saturday, March 16, 2019

The findings strengthen consideration of home treatment for patients at sufficiently low risk and raise the issue of whether hospital admission is a necessary step at all. Medscape Medical News

CABANA Published: Mixed Results, Helpful Insights

Saturday, March 16, 2019

Primary clinical outcomes were similar for catheter ablation and meds-only in the atrial fibrillation trial. But secondary ablation advantages could help inform shared decision-making, say observers. Medscape Medical News

TAVR With Evolut: Interim Results Promising in Low-Risk Patients

Saturday, March 16, 2019

The transcatheter procedure was noninferior to surgery in an interim Bayesian analysis of the primary endpoint -- death from any cause or disabling stroke at 24 months -- in a new trial involving patients with severe aortic stenosis at low surgica...